Design of an optical interferometer spacecraft

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1992.Includes bibliographical references (leaves 131-134)by Andrew Marc Nisbet.M.S

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Secular changes in sedimentation systems and sequence stratigraphy

The ephemeral nature of most sedimentation processes and the fragmentary character of the sedimentary record are of first-order importance. Despite a basic uniformity of external controls on sedimentation resulting in markedly similar lithologies, facies, facies associations and depositional elements within the rock record across time, there are a number of secular changes, particularly in rates and intensities of processes that resulted in contrasts between preserved Precambrian and Phanerozoic successions. Secular change encompassed (1) variations in mantle heat, rates of plate drift and of continental crustal growth, the gravitational effects of the Moon, and in rates of weathering, erosion, transport, deposition and diagenesis; (2) a decreasing planetary rotation rate over time; (3) no vegetation in the Precambrian, but prolific microbial mats, with the opposite pertaining to the Phanerozoic; (4) the long-term evolution of the hydrosphere-atmosphere-biosphere system. A relatively abrupt and sharp turning point was reached in the Neoarchaean, with spikes in mantle plume flux and tectonothermal activity and possibly concomitant onset of the supercontinent cycle. Substantial and irreversible change occurred subsequently in the Palaeoproterozoic, whereby the dramatic change from reducing to oxidizing volcanic gases ushered in change to an oxic environment, to be followed at ca. 2.4-2.3. Ga by the "Great Oxidation Event" (GOE); rise in atmospheric oxygen was accompanied by expansion of oxygenic photosynthesis in the cyanobacteria. A possible global tectono-thermal "slowdown" from ca. 2.45-2.2. Ga may have separated a preceding plate regime which interacted with a higher energy mantle from a ca. 2.2-2.0. Ga Phanerozoic-style plate tectonic regime; the "slowdown" period also encompassed the first known global-scale glaciation and overlapped with the GOE. While large palaeodeserts emerged from ca. 2.0-1.8. Ga, possibly associated with the evolution of the supercontinent cycle, widespread euxinia by ca. 1.85. Ga ushered in the "boring billion" year period. A second time of significant and irreversible change, in the Neoproterozoic, saw a second major oxidation event and several low palaeolatitude Cryogenian (740-630. Ma) glaciations. With the veracity of the "Snowball Earth" model for Neoproterozoic glaciation being under dispute, genesis of Pre-Ediacaran low-palaeolatitude glaciation remains enigmatic. Ediacaran (635-542. Ma) glaciation with a wide palaeolatitudinal range contrasts with the circum-polar nature of Phanerozoic glaciation. The observed change from low latitude to circum-polar glaciation parallels advent and diversification of the Metazoa and the Neoproterozoic oxygenation (ca. 580. Ma), and was succeeded by the Ediacaran-Cambrian transition which ushered in biomineralization, with all its implications for the chemical sedimentary record. © 2012 International Association for Gondwana Research.Patrick G. Eriksson, Santanu Banerjee, Octavian Catuneanu, Patricia L. Corcoran, Kenneth A. Eriksson, Eric E. Hiatt, Marc Laflamme, Nils Lenhardt, Darrel G.F. Long, Andrew D. Miall, Michael V. Mints, Peir K. Pufahl, Subir Sarkar, Edward L. Simpson, George E. William